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Grenoble, 20 August 2019 ‘Kissing loops’ in RNA molecule essential for its role in tumour suppression A team of researchers in the Marcia group at EMBL Grenoble, France, have discovered that the tumour suppressor MEG3 adopts a complex three-dimensional structure to fulfil its function. Furthermore, they were able to fine-tune its activity by targeted manipulation of this architecture. The results of this study, published in Molecular Cell, might help to advance diagnosis and treatment of certain types of cancer.
Hinxton, 14 August 2019 Pinpointing the molecular mechanisms of ageing Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), the Babraham Institute and collaborators have used the epigenetic clock to explore the molecular mechanisms that may drive ageing in humans. They found one gene, called NSD1, that seems to be closely linked to the process. This type of research could advance our understanding of ageing.
Grenoble, 22 July 2019 Toxin responsible for Legionella growth identified A team of scientists led by EMBL group leader Sagar Bhogaraju and Ivan Dikic of Goethe University, Frankfurt, discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein Calmodulin to its own advantage in one of the classic examples of pathogenic bacteria exploiting the human molecular machinery and turning it against us. This makes SidJ an ideal target to curb Legionella infection. The results have been published in Nature.
Heidelberg, 16 July 2019 Dieter Schwarz Foundation supports Life Science Alliance Today, representatives from the Dieter Schwarz Foundation announced funding to the European Molecular Biology Laboratory (EMBL) to support its collaborative effort with the Stanford University School of Medicine, called the EMBL | Stanford Life Science Alliance.
Heidelberg, 15 July 2019 Does rearranging chromosomes affect their function? Molecular biologists long thought that domains in the genome’s 3D organisation control how genes are expressed. After studying highly rearranged chromosomes in fruit flies, EMBL researchers from the Furlong and Korbel groups now reveal that while this is the case for some genes, their results challenge the generality of this for many others. Their results, published in Nature Genetics on 15 July, reveal an uncoupling between the 3D genome organisation – also called chromatin topology – and gene expression.
Hinxton, 2 July 2019 A new home for biological images EMBL’s European Bioinformatics Institute (EMBL-EBI) is expanding its remit to include bioimaging data. Through its new, dedicated resource for biological images, called the BioImage Archive, EMBL-EBI aims to make it easier for researchers around the world to store, share, access and analyse biological images.
Hamburg, 4 June 2019 Discover the research schooner Tara and her new microplastics mission in the Hamburg harbour on 17 June The Tara Ocean Foundation and the European Molecular Biology Laboratory (EMBL) in Hamburg invite journalists to a press conference on the rising threat of microplastics in European rivers and the ocean. The press conference also provides the opportunity to discover the interdisciplinary research of EMBL, major partner of the Tara expeditions and the place where the idea for Tara Oceans (2009–2013) was born.
Grenoble, 3 June 2019 Snapshots of the flu virus replication machine in action pave the way for new drugs Researchers from the Cusack group in EMBL Grenoble have, for the first time, observed different functional states of the influenza virus polymerase as it is actively transcribing. These results, published in Nature Structural & Molecular Biology, provide valuable information for the next generation of anti-influenza drugs.
Barcelona, Grenoble, Hamburg, Heidelberg, Hinxton, Rome, 16 May 2019 The origins of plastic pollution at sea The Tara Ocean Foundation launches Mission Microplastics: the exploration of 10 European rivers to assess the impact of plastics from the land to the sea. EMBL will organise special events during the upcoming ports of call at or near EMBL sites: London, Hamburg, Rome, Marseille and Barcelona.
Heidelberg, 29 April 2019 New 3D microscope visualises fast biological processes better than ever Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg have combined their expertise to develop a new type of microscope. The revolutionary new light-field microscopy system makes it possible to study fast biological processes, creating up to 200 3D images per second. Initial tests have already delivered new insights into the movement of blood cells in a heart.
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