Wandzik JM, Kouba T, Cusack S. (2020)

Structure and function of influenza polymerase.

Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a038372
Europe PMC | doi

Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Günther S, Cusack S, Grünewald K, Rosenthal M. (2020)

Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein.

Nucleic Acids Res. doi: 10.1093/nar/gkaa253
Europe PMC | doi

Wandzik JM, Kouba T, Karuppasamy M, Pflug A, Drncova P, Provaznik J, Azevedo N, Cusack S. (2020)

A structure-based model for the complete transcription cycle of influenza polymerase.

Cell doi: 10.1016/j.cell.2020.03.061
Europe PMC | doi

Liu RJ, Long T, Li H, Zhao J, Li J, Wang M, Palencia A, Lin J, Cusack S, Wang ED. (2020)

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.

Nucleic Acids Res. doi: 10.1093/nar/gkaa189
Europe PMC | doi

Olschewski S, Cusack S, Rosenthal M. (2020)

The cap-snatching mechanism of bunyaviruses.

Trends Microbiol 28(4):293-303. doi: 10.1016/j.tim.2019.12.006
Europe PMC | doi

Kouba T, Drncová P, Cusack S. (2019)

Structural snapshots of actively transcribing influenza polymerase.

Nat. Struct. Mol. Biol. 26(6):460-470. doi: 10.1038/s41594-019-0232-z
Europe PMC | doi

Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S. (2018)

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.

Nat Commun 9(1) doi: 10.1038/s41467-018-06451-3
Europe PMC | doi

iNEXT Consortium. (2018)

iNEXT: a European facility network to stimulate translational structural biology.

FEBS Lett. 592(12) doi: 10.1002/1873-3468.13062
Europe PMC | doi

Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S. (2018)

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

Sci Rep 8(1) doi: 10.1038/s41598-018-27890-4
Europe PMC | doi

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S. (2018)

Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Nat Commun 9(1) doi: 10.1038/s41467-018-04643-5
Europe PMC | doi

Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K. (2018)

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

Nat Commun 9(1) doi: 10.1038/s41467-018-04214-8
Europe PMC | doi

Schulze WM, Stein F, Rettel M, Nanao M, Cusack S. (2018)

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

Nat Commun 9(1) doi: 10.1038/s41467-018-04142-7
Europe PMC | doi

Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze WM, Cusack S. (2018)

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.

Nucleic Acids Res. 46(2) doi: 10.1093/nar/gkx1210
Europe PMC | doi

Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj I. (2018)

Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase.

J. Mol. Biol. 430(1) doi: 10.1016/j.jmb.2017.10.024
Europe PMC | doi

Cusack S, Müller CW. (2017)

Editorial overview: Protein-nucleic acid interactions: An expanding universe.

Curr. Opin. Struct. Biol. 47 doi: 10.1016/j.sbi.2017.11.004
Europe PMC | doi

Schulze WM, Cusack S. (2017)

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

Nat Commun 8(1) doi: 10.1038/s41467-017-01402-w
Europe PMC | doi

Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S. (2017)

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

PLoS One 12(5) doi: 10.1371/journal.pone.0177161
Europe PMC | doi

Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S. (2017)

Structural insights into reptarenavirus cap-snatching machinery.

PLoS Pathog 13(5) doi: 10.1371/journal.ppat.1006400
Europe PMC | doi

Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S. (2017)

Structural insights into RNA synthesis by the influenza virus transcription-replication machine.

Virus Res. 234(16):30782. doi: 10.1016/j.virusres.2017.01.013
Europe PMC | doi

Reich S, Guilligay D, Cusack S. (2017)

An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.

Nucleic Acids Res. 45(6):3353-3368. doi: 10.1093/nar/gkx043
Europe PMC | doi

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. (2017)

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

EMBO Mol Med 9(3):385-394. doi: 10.15252/emmm.201607370
Europe PMC | doi

Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S. (2017)

Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

Nature 541(7635):117-121. doi: 10.1038/nature20594
Europe PMC | doi

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J. (2016)

Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Nat Commun 7 doi: 10.1038/ncomms12928
Europe PMC | doi

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. (2016)

Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase.

Antimicrob. Agents Chemother. 60(8):4886-4895. doi: 10.1128/AAC.00820-16
Europe PMC | doi

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. (2016)

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

Antimicrob. Agents Chemother. 60(10) doi: 10.1128/AAC.00873-16
Europe PMC | doi

Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S. (2016)

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.

PLoS Pathog. 12(6) doi: 10.1371/journal.ppat.1005636
Europe PMC | doi

Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T. (2016)

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

Sci Rep 6 doi: 10.1038/srep24727
Europe PMC | doi

Aleksandrov A, Palencia A, Cusack S, Field M. (2016)

Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate

J PHYS CHEM B 120(19):4388-4398. doi: 10.1021/acs.jpcb.6b02387
Europe PMC | doi

Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S. (2016)

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.

Mol. Cell 62(4):586-602. doi: 10.1016/j.molcel.2016.04.021
Europe PMC | doi

Avilov S, Magnus J, Cusack S, Naffakh N. (2016)

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.

PLoS ONE 11(3) doi: 10.1371/journal.pone.0149986
Europe PMC | doi

Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S. (2016)

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Mol. Cell 61(1):125-137. doi: 10.1016/j.molcel.2015.11.016
Europe PMC | doi

Reguera J, Gerlach P, Cusack S. (2016)

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases.

Curr. Opin. Struct. Biol. 36:75-84. doi: 10.1016/j.sbi.2016.01.002
Europe PMC | doi

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E. (2015)

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Nature 527(7576):114-117. doi: 10.1038/nature15525
Europe PMC | doi

Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S. (2015)

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

ACS Chem Biol 10(10):2277-2285. doi: 10.1021/acschembio.5b00291
Europe PMC | doi

Roch FF, Hinterkörner G, Menke J, Tang GQ, Cusack S, Butzendobler B, Buschmann H, Datta K, Wolkerstorfer A. (2015)

An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex.

Assay Drug Dev Technol 13(8):488-506. doi: 10.1089/adt.2015.668
Europe PMC | doi

Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D. (2015)

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

BMC Biol. 13:54. doi: 10.1186/s12915-015-0166-9
Europe PMC | doi

Gerlach P, Malet H, Cusack S, Reguera J. (2015)

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.

Cell 161(6):1267-1279. doi: 10.1016/j.cell.2015.05.006
Europe PMC | doi

Pflug A, Guilligay D, Reich S, Cusack S. (2014)

Structure of influenza A polymerase bound to the viral RNA promoter.

Nature 516(7531):355-360. doi: 10.1038/nature14008
Europe PMC | doi

Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S. (2014)

Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Nature 516(7531):361-366. doi: 10.1038/nature14009
Europe PMC | doi

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S. (2014)

Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.

RNA 20(12):1955-1962. doi: 10.1261/rna.047209.114
Europe PMC | doi

Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D. (2014)

RIG-I Self-Oligomerization Is Either Dispensable or Very Transient for Signal Transduction

PLoS ONE 9(9):e108770. doi: 10.1371/journal.pone.0108770
Europe PMC | doi

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS. (2014)

RNA clamping by vasa assembles a piRNA amplifier complex on transposon transcripts.

Cell 157(7):1698-1711. doi: 10.1016/j.cell.2014.05.018
Europe PMC | doi

Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I. (2014)

The physiological target for LeuRS translational quality control is norvaline

EMBO J. 33(15):1639-1653. doi: 10.15252/embj.201488199
Europe PMC | doi

Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A. (2014)

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex

Genes Dev. 28(9):929-942. doi: 10.1101/gad.240200.114
Europe PMC | doi

Reguera J, Cusack S, Kolakofsky D. (2014)

Segmented negative strand RNA virus nucleoprotein structure

Curr Opin Virol 5C:7-15. doi: 10.1016/j.coviro.2014.01.003
Europe PMC | doi

Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S. (2014)

Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus

Structure 22(3):452-465. doi: 10.1016/j.str.2013.12.014
Europe PMC | doi

Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S. (2014)

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Nucleic Acids Res. 42(4):2673-2686. doi: 10.1093/nar/gkt1197
Europe PMC | doi

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S. (2014)

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains

PLoS ONE 9(1):e84973. doi: 10.1371/journal.pone.0084973
Europe PMC | doi

Hallais M, Pontvianne F, Andersen PR, Clerici M, Lener D, Benbahouche Nel H, Gostan T, Vandermoere F, Robert MC, Cusack S, Verheggen C, Jensen TH, Bertrand E. (2013)

CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing

Nat. Struct. Mol. Biol. 20(12):1358-1366. doi: 10.1038/nsmb.2720
Europe PMC | doi

Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. (2013)

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

J. Med. Chem. 56(21):8915-8930. doi: 10.1021/jm401369y
Europe PMC | doi

Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. (2013)

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9

Cell Rep 5(1):13-20. doi: 10.1016/j.celrep.2013.08.035
Europe PMC | doi

Datta K, Wolkerstorfer A, Szolar OH, Cusack S, Klumpp K. (2013)

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

Nucleic Acids Res. 41(17):8289-8299. doi: 10.1093/nar/gkt603
Europe PMC | doi

Klemm C, Reguera J, Cusack S, Zielecki F, Kochs G, Weber F. (2013)

Systems to establish bunyavirus genome replication in the absence of transcription

J. Virol. 87(14):8205-8212. doi: 10.1128/jvi.00371-13
Europe PMC | doi

Reguera J, Malet H, Weber F, Cusack S. (2013)

Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

Proc. Natl. Acad. Sci. U.S.A. 110(18):7246-7251. doi: 10.1073/pnas.1302298110
Europe PMC | doi

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. (2013)

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria

Antimicrob. Agents Chemother. 57(3):1394-1403. doi: 10.1128/aac.02058-12
Europe PMC | doi

Li L, Palencia A, Lukk T, Li Z, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT. (2013)

Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

Proc. Natl. Acad. Sci. U.S.A. 110(10):3817-3822. doi: 10.1073/pnas.1218374110
Europe PMC | doi

Chopra S, Palencia A, Virus C, Tripathy A, Temple BR, Velazquez-Campoy A, Cusack S, Reader JS. (2013)

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

Nat Commun 4:1417. doi: 10.1038/ncomms2421
Europe PMC | doi

Avilov SV, Moisy D, Naffakh N, Cusack S. (2012)

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

Vaccine 30(51):7411-7417. doi: 10.1016/j.vaccine.2012.09.077
Europe PMC | doi

Kolakofsky D, Kowalinski E, Cusack S. (2012)

A structure-based model of RIG-I activation

RNA 18(12):2118-2127. doi: 10.1261/rna.035949.112
Europe PMC | doi

Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A, Kadlec J. (2012)

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

Mol. Cell 48(4):587-600. doi: 10.1016/j.molcel.2012.09.014
Europe PMC | doi

Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S. (2012)

The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors

RNA 18(11):2056-2072. doi: 10.1261/rna.034181.112
Europe PMC | doi

Palencia A, Crépin T, Vu MT, Lincecum TL Jr, Martinis SA, Cusack S. (2012)

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

Nat. Struct. Mol. Biol. 19(7):677-684. doi: 10.1038/nsmb.2317
Europe PMC | doi

Avilov SV, Moisy D, Munier S, Schraidt O, Naffakh N, Cusack S. (2012)

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

J. Virol. 86(3):1433-1448. doi: 10.1128/jvi.05820-11
Europe PMC | doi

Kowalinski E, Louber J, Gerlier D, Cusack S. (2012)

[RIG-I: a viral RNA detector molecular switch]

Med Sci (Paris) 28(2):136-138. doi: 10.1051/medsci/2012282006
Europe PMC | doi

Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S. (2012)

Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase

PLoS Pathog. 8(8):e1002831. doi: 10.1371/journal.ppat.1002831
Europe PMC | doi

Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S, Chroboczek J. (2012)

The structural basis for the integrity of adenovirus Ad3 dodecahedron

PLoS ONE 7(9):e46075. doi: 10.1371/journal.pone.0046075
Europe PMC | doi

Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S. (2011)

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

Cell 147(2):423-435. doi: 10.1016/j.cell.2011.09.039
Europe PMC | doi

Perrakis A, Musacchio A, Cusack S, Petosa C. (2011)

Investigating a macromolecular complex: the toolkit of methods

J. Struct. Biol. 175(2):106-112. doi: 10.1016/j.jsb.2011.05.014
Europe PMC | doi

Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A. (2011)

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1

Nat. Struct. Mol. Biol. 18(2):142-149. doi: 10.1038/nsmb.1960
Europe PMC | doi

Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M. (2011)

A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase

J. Mol. Biol. 405(4):1056-1069. doi: 10.1016/j.jmb.2010.11.049
Europe PMC | doi

Boivin S, Cusack S, Ruigrok RW, Hart DJ. (2010)

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

J. Biol. Chem. 285(37):28411-28417. doi: 10.1074/jbc.r110.117531
Europe PMC | doi

Crépin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW. (2010)

Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit

J. Virol. 84(18):9096-9104. doi: 10.1128/jvi.00995-10
Europe PMC | doi

Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M. (2010)

Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX

RNA 16(6):1205-1216. doi: 10.1261/rna.2009910
Europe PMC | doi

Huet S, Avilov SV, Ferbitz L, Daigle N, Cusack S, Ellenberg J. (2010)

Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy

J. Virol. 84(3):1254-1264. doi: 10.1128/jvi.01533-09
Europe PMC | doi

Ruigrok RW, Crépin T, Hart DJ, Cusack S. (2010)

Towards an atomic resolution understanding of the influenza virus replication machinery

Curr. Opin. Struct. Biol. 20(1):104-113. doi: 10.1016/j.sbi.2009.12.007
Europe PMC | doi

Chenavas S, Guilligay D, Cusack S, Hart DJ, Ruigrok RWH, Crépin T. (2010)

Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe [Advances in the structural study and molecular comprehension of the transcription mechanism of influenza virus]

Virologie 14(6):435-445. doi: 10.1684/vir.2010.0328
Europe PMC | doi

Reguera J, Weber F, Cusack S. (2010)

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription

PLoS Pathog. 6(9):e1001101. doi: 10.1371/journal.ppat.1001101
Europe PMC | doi

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S. (2009)

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

EMBO J. 28(15):2293-2306. doi: 10.1038/emboj.2009.175
Europe PMC | doi

Seiradake E, Mao W, Hernandez V, Baker SJ, Plattner JJ, Alley MR, Cusack S. (2009)

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles

J. Mol. Biol. 390(2):196-207. doi: 10.1016/j.jmb.2009.04.073
Europe PMC | doi

Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA. (2009)

Structure and functional relevance of the Slit2 homodimerization domain

EMBO Rep. 10(7):736-741. doi: 10.1038/embor.2009.95
Europe PMC | doi

Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M. (2009)

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis

J. Med. Chem. 52(12):3666-3678. doi: 10.1021/jm801609s
Europe PMC | doi

Brooks MA, Ravelli RB, McCarthy AA, Strub K, Cusack S. (2009)

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

Acta Crystallogr. D Biol. Crystallogr. 65(Pt 5):421-433. doi: 10.1107/s0907444909005484
Europe PMC | doi

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW. (2009)

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Nature 458(7240):914-918. doi: 10.1038/nature07745
Europe PMC | doi

Dias A, Bouvier D, Cusack S, Ruigrok RW, Crépin T. (2009)

[New strategy for targeting influenza virus replication]

Med Sci (Paris) 25(4):352-354. doi: 10.1051/medsci/2009254352
Europe PMC | doi

Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ. (2009)

The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution

PLoS Pathog. 5(1):e1000277. doi: 10.1371/journal.ppat.1000277
Europe PMC | doi

Worch R, Jankowska-Anyszka M, Niedzwiecka A, Stepinski J, Mazza C, Darzynkiewicz E, Cusack S, Stolarski R. (2009)

Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex

J. Mol. Biol. 385(2):618-627. doi: 10.1016/j.jmb.2008.10.092
Europe PMC | doi

El Bakkouri M, Seiradake E, Cusack S, Ruigrok RW, Schoehn G. (2008)

Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre

Virology 378(1):169-176. doi: 10.1016/j.virol.2008.05.011
Europe PMC | doi

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. (2008)

The structural basis for cap binding by influenza virus polymerase subunit PB2

Nat. Struct. Mol. Biol. 15(5):500-506. doi: 10.1038/nsmb.1421
Europe PMC | doi

Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ. (2008)

Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit

PLoS Pathog. 4(8):e1000136. doi: 10.1371/journal.ppat.1000136
Europe PMC | doi

Crépin T, Cusack S. (2007)

[Trap the product to specifically inhibit the enzyme]

Med Sci (Paris) 23(12):1087-1089. doi: 10.1051/medsci/200723121087
Europe PMC | doi

De la Peña M, Kyrieleis OJ, Cusack S. (2007)

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

EMBO J. 26(23):4913-4925. doi: 10.1038/sj.emboj.7601912
Europe PMC | doi

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

Acta Crystallogr. D Biol. Crystallogr. 63(Pt 9):961-968. doi: 10.1107/s0907444907035470
Europe PMC | doi

Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Structural insights into the Slit-Robo complex

Proc. Natl. Acad. Sci. U.S.A. 104(38):14923-14928. doi: 10.1073/pnas.0705310104
Europe PMC | doi

Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. (2007)

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1)

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 8):689-691. doi: 10.1107/S1744309107033027
Europe PMC | doi

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR. (2007)

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

Science 316(5832):1759-1761. doi: 10.1126/science.1142189
Europe PMC | doi

Budayova-Spano M, Dauvergne F, Audiffren M, Bactivelane T, Cusack S. (2007)

A methodology and an instrument for the temperature-controlled optimization of crystal growth

Acta Crystallogr. D Biol. Crystallogr. 63(Pt 3):339-347. doi: 10.1107/s0907444906054230
Europe PMC | doi

Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K. (2007)

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

J. Mol. Biol. 366(5):1545-1557. doi: 10.1016/j.jmb.2006.12.049
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Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ. (2007)

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

Nat. Struct. Mol. Biol. 14(3):229-233. doi: 10.1038/nsmb1212
Europe PMC | doi

Manon F, Favier A, Núñez G, Simorre JP, Cusack S. (2007)

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK

J. Mol. Biol. 365(1):160-174. doi: 10.1016/j.jmb.2006.09.067
Europe PMC | doi

Torreira E, Schoehn G, Fernández Y, Jorba N, Ruigrok RW, Cusack S, Ortín J, Llorca O. (2007)

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer

Nucleic Acids Res. 35(11):3774-3783. doi: 10.1093/nar/gkm336
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